Ghr^tm1Arge
Targeted Allele Detail

Summary

• Symbol: Ghr^tm1Arge
• Name: growth hormone receptor; targeted mutation 1, Argiris Efstratiadis
• MGI ID: MGI:2681515
• Synonyms: Ghr-, Ghr^ex7-8
• Gene: Ghr Location: Chr15:3347237-3612834 bp, - strand Genetic Position: Chr15, 1.84 cM
• Alliance: Ghr^tm1Arge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66913
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced genomic sequences including exons 7, 8a and 8. Northern blot analysis demonstrated that no detectable transcript was expressed from this allele, and western blot analysis confirmed that no encoded protein was present in hepatic microsomal membrane extracts derived from homozygous mice. (J:66913)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghr Mutation: 50 strains or lines available

References

• Original: J:66913 Lupu F, et al., Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol. 2001 Jan 1;229(1):141-62
• All: 1 reference(s)