Fbln5^tm1Krc
Targeted Allele Detail

Summary

• Symbol: Fbln5^tm1Krc
• Name: fibulin 5; targeted mutation 1, Kenneth R Chien
• MGI ID: MGI:2681527
• Synonyms: fibulin-5-
• Gene: Fbln5 Location: Chr12:101712824-101785314 bp, - strand Genetic Position: Chr12, 51.29 cM, cytoband F1
• Alliance: Fbln5^tm1Krc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86753
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a cassette containing lacZ and neo replaced the first 4 exons of the endogenous gene. Transcript was undetected in homozygous mutant mice by Northern blot analysis and in situ hybridization of the pulmonary artery and lungs. (J:86753)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbln5 Mutation: 37 strains or lines available

References

• Original: J:86753 Nakamura T, et al., Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 Jan 10;415(6868):171-5
• All: 5 reference(s)