Epha3^tm1Abn
Targeted Allele Detail

Summary

• Symbol: Epha3^tm1Abn
• Name: Eph receptor A3; targeted mutation 1, Arthur Brown
• MGI ID: MGI:2681606
• Synonyms: Efna3^tm1Abn, EphA3^-
• Gene: Epha3 Location: Chr16:63363897-63684538 bp, - strand Genetic Position: Chr16, 36.49 cM
• Alliance: Epha3^tm1Abn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86478
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a neomycin resistance gene. Western blot analysis on E12.5 spinal cord protein extracts demonstrated the absence of gene product. (J:86478)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Epha3 Mutation: 80 strains or lines available

References

• Original: J:86478 Vaidya A, et al., EphA3 null mutants do not demonstrate motor axon guidance defects. Mol Cell Biol. 2003 Nov;23(22):8092-8
• All: 9 reference(s)