Irx2^tm1Hui
Targeted Allele Detail

Summary

• Symbol: Irx2^tm1Hui
• Name: Iroquois homeobox 2; targeted mutation 1, Chi-Chung Hui
• MGI ID: MGI:2681629
• Synonyms: Irx2^LacZ/LacZ (-)
• Gene: Irx2 Location: Chr13:72776939-72782317 bp, + strand Genetic Position: Chr13, 39.23 cM
• Alliance: Irx2^tm1Hui page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86477
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 and intron 1 were replaced by an IRES-lacZ reporter gene followed by a floxed PGK-neo cassete. PGK-neo was excised in vivo by crossing carriers with NLS-Cre transgenic mice which express cre ubiquitously. Western blot analysis indicated that the protein product was not produced. (J:86477)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irx2 Mutation: 25 strains or lines available

References

• Original: J:86477 Lebel M, et al., The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice. Mol Cell Biol. 2003 Nov;23(22):8216-25
• All: 1 reference(s)