Gnaq^Mhdadsk1
Chemically induced Allele Detail

Summary

• Symbol: Gnaq^Mhdadsk1
• Name: guanine nucleotide binding protein, alpha q polypeptide; Martin Hrabe de Angelis dark skin 1
• MGI ID: MGI:2681766
• Synonyms: dark skin 1, Dsk1, Gnaq^Dsk1
• Gene: Gnaq Location: Chr19:16110195-16364827 bp, + strand Genetic Position: Chr19, 11.01 cM
• Alliance: Gnaq^Mhdadsk1 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A single base pair mutation causes a non-conservative sequence change of valine to methionine at position 179 of the encoded protein. The mutant protein shows hypermorphic activity by genetic interaction tests with other mutant alleles. (J:92947)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gnaq Mutation: 24 strains or lines available

References

• Original: J:81301 Fitch KR, et al., Genetics of dark skin in mice. Genes Dev. 2003 Jan 15;17(2):214-28
• All: 3 reference(s)