Tas1r2^tm1Csz
Targeted Allele Detail

Summary

• Symbol: Tas1r2^tm1Csz
• Name: taste receptor, type 1, member 2; targeted mutation 1, Charles S Zuker
• MGI ID: MGI:2681886
• Synonyms: T1R2^-
• Gene: Tas1r2 Location: Chr4:139380849-139397591 bp, + strand Genetic Position: Chr4, 70.82 cM
• Alliance: Tas1r2^tm1Csz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86474
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 and 6 were replaced with a PGK-neo cassette inserted by homologous recombination. Protein was undetected by in situ hybridization of homozygous mutant taste bud sections. (J:86474)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tas1r2 Mutation: 50 strains or lines available

Notes

Results reported in J:86474 were in conjunction with a Tas1r3^Sac-b "taster" allele, however qualitatively similar data was obtained in conjunction with a Tas1r3^sac-d "non-taster" allele.

References

• Original: J:86474 Zhao GQ, et al., The receptors for mammalian sweet and umami taste. Cell. 2003 Oct 31;115(3):255-66
• All: 18 reference(s)