Grxcr1^pi-tde
Transgenic Allele Detail

Summary

• Symbol: Grxcr1^pi-tde
• Name: glutaredoxin, cysteine rich 1; tasmanian devil
• MGI ID: MGI:2681910
• Synonyms: PLAP26
• Gene: Grxcr1 Location: Chr5:68189178-68323741 bp, + strand Genetic Position: Chr5, 36.59 cM
• Alliance: Grxcr1^pi-tde page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/Ca)F2

Transgene description

• Transgene Type: Transgenic
• Mutation: Insertion
• Mutation details: Multiple copies of a transgenic construct, consisting of the Roux Sarcoma Virus promoter adjoined to the entire coding region of the human placental alkaline phosphatase gene, inserted in tandem array in the middle of chromosome 5. Phenotypic characteristics segregated with transgene and were not observed in a different line with similar levels of expression, indicating the phenotype was largely due to the site of insertion. A non-complementation test demonstrated that the insertional mutation is allelic to pirouette. Further molecular analysis showed that the insertion is located in intron 1, 32 kb upstream of exon 2. (J:86585, J:93174, J:156811)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grxcr1 Mutation: 23 strains or lines available

References

• Original: J:86585 Erven A, et al., A novel stereocilia defect in sensory hair cells of the deaf mouse mutant Tasmanian devil. Eur J Neurosci. 2002 Oct;16(8):1433-41
• All: 4 reference(s)