Nbn^tm1Zqw
Targeted Allele Detail

Summary

• Symbol: Nbn^tm1Zqw
• Name: nibrin; targeted mutation 1, Zhao-Qi Wang
• MGI ID: MGI:2682000
• Synonyms: Nbn^-, Nbn^ins-6
• Gene: Nbn Location: Chr4:15957925-15992589 bp, + strand Genetic Position: Chr4, 6.66 cM, cytoband A
• Alliance: Nbn^tm1Zqw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86563
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Exon 6 was disrupted by the insertion of a neomycin selection cassette. (J:86563)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Nbn^tm1Zqw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nbn Mutation: 59 strains or lines available

References

• Original: J:86563 Dumon-Jones V, et al., Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis. Cancer Res. 2003 Nov 1;63(21):7263-9
• All: 4 reference(s)