Icam2^tm1Jcgr
Targeted Allele Detail

Summary

• Symbol: Icam2^tm1Jcgr
• Name: intercellular adhesion molecule 2; targeted mutation 1, Jose-Carlos Gutierrez-Ramos
• MGI ID: MGI:2682009
• Synonyms: ICAM-2-
• Gene: Icam2 Location: Chr11:106268482-106278901 bp, - strand Genetic Position: Chr11, 69.09 cM
• Alliance: Icam2^tm1Jcgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54748
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette. Protein was undetected by immunohistochemical analysis of homozygous mutant lung, kidney, liver, and spleen tissues. The absence of protein was further confirmed by flow cytometry, which showed no protein expression on the surface of homozygous mutant thymocytes, T or B lymphocytes, or myeloid cells. (J:54748)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icam2 Mutation: 15 strains or lines available

References

• Original: J:54748 Gerwin N, et al., Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. Immunity. 1999 Jan;10(1):9-19
• All: 17 reference(s)