Cacna1h^tm1Kcam
Targeted Allele Detail

Summary

• Symbol: Cacna1h^tm1Kcam
• Name: calcium channel, voltage-dependent, T type, alpha 1H subunit; targeted mutation 1, Kevin P Campbell
• MGI ID: MGI:2682015
• Synonyms: alpha13.2^-, Cav3.2^-
• Gene: Cacna1h Location: Chr17:25593259-25652759 bp, - strand Genetic Position: Chr17, 12.53 cM
• Alliance: Cacna1h^tm1Kcam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86616
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6, which encodes residues 216 through 267, was replaced with a floxed neo cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of RNA obtained from homozygous mutant testes. Similarly, Western blot analysis of extracts from homozygous mutant brain tissue indicated an absence of normal protein. (J:86616)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cacna1h Mutation: 98 strains or lines available

References

• Original: J:86616 Chen CC, et al., Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels. Science. 2003 Nov 21;302(5649):1416-8
• All: 52 reference(s)