Gja1^M1Jrt
Chemically induced Allele Detail

Summary

• Symbol: Gja1^M1Jrt
• Name: gap junction protein, alpha 1; mutation 1, Janet Rossant
• MGI ID: MGI:2682016
• Synonyms: Cx43^G60S, Gja1^1Jrt, Gja1^Jrt
• Gene: Gja1 Location: Chr10:56253297-56266519 bp, + strand Genetic Position: Chr10, 28.64 cM
• Alliance: Gja1^M1Jrt page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation in was identified as GGT Glycine to AGT Serine (G 60 S) in the first extracellular loop. This Glycine is conserved in human, rat, cow, hamster, chick and zebrafish. (J:86757, J:101733)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gja1 Mutation: 60 strains or lines available

References

• Original: J:86757 Rossant J, ENU mutants from the Center of Modeling Human Disease. MGI Direct Data Submission. 2003
• All: 20 reference(s)