Ubr2^tm1Ytkw
Targeted Allele Detail

Summary

• Symbol: Ubr2^tm1Ytkw
• Name: ubiquitin protein ligase E3 component n-recognin 2; targeted mutation 1, Yong Tae Kwon
• MGI ID: MGI:2682037
• Synonyms: UBR2^-
• Gene: Ubr2 Location: Chr17:47239221-47321482 bp, - strand Genetic Position: Chr17, 22.91 cM
• Alliance: Ubr2^tm1Ytkw page

Abnormal development of the central nervous system in Ubr1^tm1Avar/Ubr1^tm1Avar Ubr2^tm1Ytkw/Ubr2^tm1Ytkw embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86438
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: DNA from codon 7 (Cys) of exon 3 through codon 16 (His) of exon 6 was replaced in frame with the nuclear localization signal(NLS)-lacZ marker gene. No beta-galactosidase activity was observed however. Low levels of gene transcript could be detected by Northern blot. (J:86438)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubr2 Mutation: 86 strains or lines available

References

• Original: J:86438 Kwon YT, et al., Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Mol Cell Biol. 2003 Nov;23(22):8255-71
• All: 7 reference(s)