Gna11^Mhdadsk7
Chemically induced Allele Detail

Summary

• Symbol: Gna11^Mhdadsk7
• Name: guanine nucleotide binding protein, alpha 11; Martin Hrabe de Angelis dark skin 7
• MGI ID: MGI:2682213
• Synonyms: dark skin 7, Dsk7, Gna11^Dsk7
• Gene: Gna11 Location: Chr10:81364558-81380996 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gna11^Mhdadsk7 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A single base pair mutation causes a non-conservative sequence change of isoleucine to valine at position 63 of the encoded protein. The mutant protein shows hypermorphic activity by genetic interaction tests with other mutant alleles. (J:92947)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gna11 Mutation: 25 strains or lines available

References

• Original: J:81301 Fitch KR, et al., Genetics of dark skin in mice. Genes Dev. 2003 Jan 15;17(2):214-28
• All: 3 reference(s)