Hmgcr^tm1Ishi
Targeted Allele Detail

Summary

• Symbol: Hmgcr^tm1Ishi
• Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; targeted mutation 1, Shun Ishibashi
• MGI ID: MGI:2682329
• Synonyms: Hmgcr-
• Gene: Hmgcr Location: Chr13:96785475-96807444 bp, - strand Genetic Position: Chr13, 50.65 cM
• Alliance: Hmgcr^tm1Ishi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86378
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.2 kb fragment extending from within exon 12 into exon 14 was replaced with a neomycin selection cassette inserted by homologous recombination. (J:86378)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hmgcr Mutation: 62 strains or lines available

References

• Original: J:86378 Ohashi K, et al., Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene. J Biol Chem. 2003 Oct 31;278(44):42936-41
• All: 1 reference(s)