Prnptm2Rcm
Targeted Allele Detail
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Symbol: |
Prnptm2Rcm |
Name: |
prion protein; targeted mutation 2, Richard C Moore |
MGI ID: |
MGI:2682351 |
Synonyms: |
Rcm0 |
Gene: |
Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
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Alliance: |
Prnptm2Rcm page
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Germline Transmission: |
Earliest citation of germline transmission:
J:42407
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A genomic fragment encompassing the entire coding region contained within exon 3 as well as approximately 1 kb of sequence 5' to exon 3 was replaced with a PGK-HPRT cassette. The deleted upstream sequence included the exon 3 splice acceptor site. RT-PCR analysis of RNA obtained from homozygous mutant brain tissue showed increased levels of chimeric transcript consisting of Prnp and Prnd sequence relative to wild-type samples.
(J:42407)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Prnp Mutation: |
142 strains or lines available
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Original: |
J:42407 Moore RC, et al., Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J Mol Biol. 1999 Oct 1;292(4):797-817 |
All: |
3 reference(s) |
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