Six1^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Six1^tm1Rsd
• Name: sine oculis-related homeobox 1; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:2682355
• Synonyms: Six1^lacZ
• Gene: Six1 Location: Chr12:73088601-73093486 bp, - strand Genetic Position: Chr12, 30.34 cM
• Alliance: Six1^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86619
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the six domain and the homeodomain was replaced with a cassette containing IRES-lacZ and PGK-neo. X-gal staining showed the expression pattern of lacZ to be similar to that of the endogenous gene. (J:86619)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six1 Mutation: 19 strains or lines available

References

• Original: J:86619 Li X, et al., Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20;426(6964):247-54
• All: 5 reference(s)