Pdgfrb^tm7Sor
Targeted Allele Detail

Summary

• Symbol: Pdgfrb^tm7Sor
• Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 7, Philippe Soriano
• MGI ID: MGI:2682372
• Synonyms: F1
• Gene: Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Pdgfrb^tm7Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86542
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A point mutation was engineered and incorporated in codon 770 of the endogenous locus via homologous recombination. The mutation results in a tyrosine to phenylalanine substitution (Y770F) at a site crucial for RasGAP signal transduction. (J:86542)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Pdgfrb^tm7Sor/Pdgfrb^tm7Sor	involves: 129S4/SvJae * C57BL/6

Phenotypes:

Affected Systems	hm1
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cardiovascular system	√
abnormal blood vessel morphology	√
abnormal pericyte morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfrb Mutation: 87 strains or lines available

References

• Original: J:86542 Tallquist MD, et al., Additive Effects of PDGF Receptor beta Signaling Pathways in Vascular Smooth Muscle Cell Development. PLoS Biol. 2003 Nov;1(2):288-99
• All: 1 reference(s)