Pdgfrb^tm8Sor
Targeted Allele Detail

Summary

• Symbol: Pdgfrb^tm8Sor
• Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 8, Philippe Soriano
• MGI ID: MGI:2682376
• Synonyms: F5
• Gene: Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Pdgfrb^tm8Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86542
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: 5 point mutations were engineered and incorporated at the endogenous locus via homologous recombination of a targeting vector. Each mutation elicited a missense mutation, ablating tyrosine residues involved in PI3-K, RasGAP, SHP-2, and PLC-gamma signal transduction. Tyrosines at codons 739, 750, 770, and 1008 are substituted with phenylalanine, and a tyrosine at 1020 is substituted with isoleucine. A single loxP site was left in intron 16. (J:86542)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfrb Mutation: 87 strains or lines available

References

• Original: J:86542 Tallquist MD, et al., Additive Effects of PDGF Receptor beta Signaling Pathways in Vascular Smooth Muscle Cell Development. PLoS Biol. 2003 Nov;1(2):288-99
• All: 1 reference(s)