Pdgfrb^tm10Sor
Targeted Allele Detail

Summary

• Symbol: Pdgfrb^tm10Sor
• Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 10, Philippe Soriano
• MGI ID: MGI:2682393
• Synonyms: Beta^T
• Gene: Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Pdgfrb^tm10Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86542
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: A frameshift mutation was generated at codon 780, resulting in a nonsense mutation at 801. This stop codon is 11 residues downstream of the RasGAP binding site and precludes the translation of the SHP-2 and PLC-gamma binding sites. (J:86542)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfrb Mutation: 87 strains or lines available

References

• Original: J:86542 Tallquist MD, et al., Additive Effects of PDGF Receptor beta Signaling Pathways in Vascular Smooth Muscle Cell Development. PLoS Biol. 2003 Nov;1(2):288-99
• All: 1 reference(s)