Hycdc^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Hycdc^C3H/HeJ
• Name: hypercapnic duty cycle; C3H/HeJ
• MGI ID: MGI:2682398
• QTL: Hycdc Location: Chr5:107561006-107561151 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 52.23 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:84151

Linkage analysis was performed on 69 (C57BL/6J x C3H/HeJ)F2 animals to identify QTLs associated with hypercapnia. Parental strain C57BL/6J exhibits decreased hypercapnic duty cycle at baseline CO(2) concentrations and increased hypercapnic duty cycle at 3% CO(2) compared to parental strain C3H/HeJ. (C57BL/6J x C3H/HeJ)F1 hybrids exhibit increased hypercapnic duty cycle at both baseline and 3% CO(2) compared to both parental strains. Genome scan was performed with 176 microsatellite markers at an average spacing of 10 cM - 15 cM with 90% coverage of the genome.

A QTL associated with hypercapnic duty cycle (Hycdc) mapped to 58 cM on mouse Chromosome 5 with LOD=4.4 at D5Mit239. The QTL interval of Hycdc spans 58 cM - 64 cM with flanking markers D5Mit7 and D5Mit97 defining a broader range. Hycdc explains approximately 30% of the phenotypic variation. Candidate genes mapping near Hycdc include Dgkq, Adrbk2, and Nos1. Sequence variations exist between C57BL/6J and C3H/HeJ for Dgkq. Nos1 knockout animals exhibit abnormal hypoxic ventilation.

References

• Original: J:84151 Schneider H, et al., Hypercapnic duty cycle is an intermediate physiological phenotype linked to mouse chromosome 5. J Appl Physiol. 2003 Jul;95(1):11-9
• All: 1 reference(s)