Hrl^{129S6/SvEvTac}
QTL Variant Detail

Summary

• QTL variant: Hrl^{129S6/SvEvTac}
• Name: herpes resistance locus; 129S6/SvEvTac
• MGI ID: MGI:2682425
• QTL: Hrl Location: Chr6:125326686-125339446 bp Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: 129S6/SvEvTac

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to herpes simplex virus compared to C57BL/6J.
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:86189

Linkage analysis was performed on 275 129S6/SvEvTac x (129S6/SvEvTac x C57BL/6J)F1 backcross animals to map the herpes resistance locus, Hrl. Parental strain 129S6/SvEvTac is susceptible to infection by HSV-1 whereas parental strain C57BL/6J is resistant. Hrl is tightly linked to Tnfrsf1a on mouse Chromosome 6 (60 cM) and may be a prime candidate gene. Animals homozygous for a mutation in Tnfrsf1a exhibit a high mortality rate when challenged with HSV-1 (LD50=320 PFU) compared to wild type C57BL/6J (LD50>10<5> PFU). Klra8, a gene responsible for resistance to infection by murine cytomegalovirus, maps near Hrl at approximately 63 cM but was excluded as a candidate gene since it does not show linkage to HVS-1-induced mortality. C57BL/6J-derived alleles confer dominant resistance to HSV-1 infection at Hrl.

A locus referred to as Sml (sex modifier locus) was also identified in the 129S6/SvEvTac x (129S6/SvEvTac x C57BL/6J)F1 backcross with no map position given by the authors. Sml affects HSV-1 resistance in female animals.

References

• Original: J:86189 Lundberg P, et al., A locus on mouse chromosome 6 that determines resistance to herpes simplex virus also influences reactivation, while an unlinked locus augments resistance of female mice. J Virol. 2003 Nov;77(21):11661-73
• All: 1 reference(s)