Slc6a9^tm1Betz
Targeted Allele Detail

Summary

• Symbol: Slc6a9^tm1Betz
• Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 9; targeted mutation 1, Heinrich Betz
• MGI ID: MGI:2682493
• Synonyms: GlyT1^-/-
• Gene: Slc6a9 Location: Chr4:117692240-117726502 bp, + strand Genetic Position: Chr4, 53.62 cM
• Alliance: Slc6a9^tm1Betz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86624
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of RNA obtained from homozygous mutant brain stem and spinal cord tissue. Similarly, Western blot analysis indicated an absence of protein in extracts from homozygous mutant brain stem and spinal cord tissue. (J:86624)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a9 Mutation: 24 strains or lines available

References

• Original: J:86624 Gomeza J, et al., Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition. Neuron. 2003 Nov 13;40(4):785-96
• All: 1 reference(s)