Nanos2^tm1Ysa
Targeted Allele Detail

Summary

• Symbol: Nanos2^tm1Ysa
• Name: nanos C2HC-type zinc finger 2; targeted mutation 1, Yumiko Saga
• MGI ID: MGI:2682606
• Synonyms: nanos2-L
• Gene: Nanos2 Location: Chr7:18721449-18722887 bp, + strand Genetic Position: Chr7, 9.45 cM
• Alliance: Nanos2^tm1Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86522
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a lacZ cassette inserted at the start codon of the first coding exon. A floxed neo cassette was inserted downstream of the coding region and was subsequently removed via cre mediated recombination. LacZ expression was detected in mutant mice. (J:86522)

Expression

In Mice Carrying this Mutation:	44 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nanos2 Mutation: 16 strains or lines available

References

• Original: J:86522 Tsuda M, et al., Conserved role of nanos proteins in germ cell development. Science. 2003 Aug 29;301(5637):1239-41
• All: 18 reference(s)