Trpv4^tm1Rck
Targeted Allele Detail

Summary

• Symbol: Trpv4^tm1Rck
• Name: transient receptor potential cation channel, subfamily V, member 4; targeted mutation 1, J M Friedman
• MGI ID: MGI:2682656
• Synonyms: trpv4^-
• Gene: Trpv4 Location: Chr5:114760213-114796482 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
• Alliance: Trpv4^tm1Rck page

Trpv4^tm1Rck/Trpv4^tm1Rck mice show protection from UVB-induced skin injury

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86560
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site was left in place of exon 12 after cre mediated recombination of a single loxP site in intron 11 and a floxed neo cassette in intron 12. Protein was undetected by Western blot analysis of homozygous mutant kidney extracts. (J:86560)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv4 Mutation: 57 strains or lines available

References

• Original: J:86560 Liedtke W, et al., Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13698-703
• All: 92 reference(s)