Sox3^tm1.1Lja
Targeted Allele Detail

Summary

• Symbol: Sox3^tm1.1Lja
• Name: SRY (sex determining region Y)-box 3; targeted mutation 1, J Larry Jameson
• MGI ID: MGI:2682663
• Synonyms: Sox3^-, Sox3^tm1Lja
• Gene: Sox3 Location: ChrX:59934972-59937036 bp, - strand Genetic Position: ChrX, 33.66 cM, cytoband A7.3-B
• Alliance: Sox3^tm1.1Lja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86431
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site remained in place of the single exon after cre mediated recombination of flanking loxP sites. A neo cassette included in the targeting vector was excised along with the endogenous sequence. (J:86431)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox3 Mutation: 7 strains or lines available

References

• Original: J:86431 Weiss J, et al., Sox3 is required for gonadal function, but not sex determination, in males and females. Mol Cell Biol. 2003 Nov;23(22):8084-91
• All: 4 reference(s)