Chst4^tm1Sdr
Targeted Allele Detail

Summary

• Symbol: Chst4^tm1Sdr
• Name: carbohydrate sulfotransferase 4; targeted mutation 1, Steven D Rosen
• MGI ID: MGI:2682796
• Synonyms: GST3^-, HEC-GlcNAc6ST -
• Gene: Chst4 Location: Chr8:110755776-110766033 bp, - strand Genetic Position: Chr8, 57.38 cM, cytoband E1
• Alliance: Chst4^tm1Sdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86759
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 98bp segment from the protein coding region was replaced with an IRES-lacZ reporter and a neomycin resistance cassette. This is predicted to delete amino acid residues 46-78 which includes the PAPS5'-phosphate binding site in the encoded protein. RT-PCR failed to detect any mRNA transcript. (J:86759, J:95268)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chst4 Mutation: 17 strains or lines available

References

• Original: J:86759 Hemmerich S, et al., Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes. Immunity. 2001 Aug;15(2):237-47
• All: 9 reference(s)