Esrra^tm1Vgi
Targeted Allele Detail

Summary

• Symbol: Esrra^tm1Vgi
• Name: estrogen related receptor, alpha; targeted mutation 1, Vincent Giguere
• MGI ID: MGI:2682818
• Synonyms: ERRalpha^-
• Gene: Esrra Location: Chr19:6888345-6899182 bp, - strand Genetic Position: Chr19, 5.08 cM
• Alliance: Esrra^tm1Vgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86433
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which encodes the amino-terminal region and an essential component of its DNA-binding domain, was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted exon encoded the N-terminal region and a zinc finger domain. Northern blot analysis of renal RNA and Western blot analysis of intestinal protein indicated an absence of normal gene product in homozygous mutant mice. (J:86433)

Expression

In Mice Carrying this Mutation:	7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esrra Mutation: 26 strains or lines available

References

• Original: J:86433 Luo J, et al., Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha. Mol Cell Biol. 2003 Nov;23(22):7947-56
• All: 33 reference(s)