Cdc25b^tm1Pjd
Targeted Allele Detail

Summary

• Symbol: Cdc25b^tm1Pjd
• Name: cell division cycle 25B; targeted mutation 1, Peter J Donovan
• MGI ID: MGI:2682953
• Synonyms: Cdc25b^-
• Gene: Cdc25b Location: Chr2:131028869-131040417 bp, + strand Genetic Position: Chr2, 63.29 cM
• Alliance: Cdc25b^tm1Pjd page

Shortened villi in the small intestine of Cdc25a^tm1Hpw/Cdc25a^tm1.1Hpw Cdc25b^tm1Pjd/Cdc25b^tm1Pjd Cdc25c^tm1Hpw/Cdc25c^tm1Hpw Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺ (TKO) mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87011
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.0 kb region encoding the phosphatase box was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of homozygous mutant MEF extracts using an N-terminal antibody. (J:87011)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc25b Mutation: 30 strains or lines available

References

• Original: J:87011 Lincoln AJ, et al., Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Nat Genet. 2002 Apr;30(4):446-9
• All: 6 reference(s)