Ecsit^tm1Gho
Targeted Allele Detail

Summary

• Symbol: Ecsit^tm1Gho
• Name: ECSIT signalling integrator; targeted mutation 1, Sankar Ghosh
• MGI ID: MGI:2683025
• Synonyms: Ecsit^-
• Gene: Ecsit Location: Chr9:21983542-21996734 bp, - strand Genetic Position: Chr9, 8.23 cM, cytoband A4
• Alliance: Ecsit^tm1Gho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86912
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site remained in place of exons 2 through 8 after homologous recombination of floxed neo cassette and its subsequent cre-mediated excision. The deleted region included exons 2 through 5, which are common to the three known splice variants. Protein was undetected in homozygous mutant ES cells by Western blot analysis. (J:86912)

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ecsit Mutation: 13 strains or lines available

References

• Original: J:86912 Xiao C, et al., Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 2003 Dec 1;17(23):2933-49
• All: 3 reference(s)