Perp^tm1Att
Targeted Allele Detail

Summary

• Symbol: Perp^tm1Att
• Name: PERP, TP53 apoptosis effector; targeted mutation 1, Laura D Attardi
• MGI ID: MGI:2683069
• Synonyms: Perp^-
• Gene: Perp Location: Chr10:18720819-18732821 bp, + strand Genetic Position: Chr10, 7.97 cM, cytoband A2
• Alliance: Perp^tm1Att page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86549
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment encompassing exons 2 and 3 were replaced with a single loxP site after cre mediated recombination of a single loxP site in intron 3 and the 5' loxP site of a floxed puromycin cassette in intron 1. Neither normal or truncated transcript was detected by Northern blot analysis of homozygous mutant ES cells treated with a DNA damaging agent. (J:86549)

Expression

In Mice Carrying this Mutation:	20 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Perp^tm1Att

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Perp Mutation: 9 strains or lines available

References

• Original: J:86549 Ihrie RA, et al., Perp is a mediator of p53-dependent apoptosis in diverse cell types. Curr Biol. 2003 Nov 11;13(22):1985-90
• All: 6 reference(s)