Sncg^tm1Vlb
Targeted Allele Detail

Summary

• Symbol: Sncg^tm1Vlb
• Name: synuclein, gamma; targeted mutation 1, Vladimir L Buchman
• MGI ID: MGI:2683142
• Synonyms: TgHSNCG^tm1VLB
• Gene: Sncg Location: Chr14:34092231-34096626 bp, - strand Genetic Position: Chr14, 20.81 cM, cytoband B-C
• Alliance: Sncg^tm1Vlb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86439
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA obtained from various tissues. Western blot analysis of total spinal cord protein indicated an absence of protein in homozygous mutant mice. (J:86439)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sncg Mutation: 16 strains or lines available

References

• Original: J:86439 Ninkina N, et al., Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene. Mol Cell Biol. 2003 Nov;23(22):8233-45
• All: 19 reference(s)