Wnk1^{Gt(OST38262)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Wnk1^{Gt(OST38262)Lex}
• Name: WNK lysine deficient protein kinase 1; gene trap OST38262, Lexicon Genetics
• MGI ID: MGI:2683145
• Synonyms: Wnk1^-, Wnk1^{Gt(VICTR37)21Lex}
• Gene: Wnk1 Location: Chr6:119900930-120015633 bp, - strand Genetic Position: Chr6, 56.86 cM
• Alliance: Wnk1^{Gt(OST38262)Lex} page

Mutation origin

• Mutant Cell Line: OST38262
• Germline Transmission: Earliest citation of germline transmission: J:86696
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector (SA-Bgeo-pA-PGK-BTK-SD) inserted downstream of the first coding exon in intron 1. The amount of transcript in various heterozygous mutant organs was observed to be reduced by 41% to 57% relative to those of wild-type. (J:86696)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST38262	CG497592 ; (MGI Seq Detail)	3' RACE	multiple
  * GRCm39; (strand of gene trap mutagenesis)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wnk1 Mutation: 115 strains or lines available

References

• Original: J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
• All: 5 reference(s)