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Smarca5tm1Ais
Targeted Allele Detail
Summary
Symbol: Smarca5tm1Ais
Name: SNF2 related chromatin remodeling ATPase 5; targeted mutation 1, Art I Skoultchi
MGI ID: MGI:2683154
Synonyms: Snf2h-
Gene: Smarca5  Location: Chr8:81426572-81466088 bp, - strand  Genetic Position: Chr8, 38.41 cM
Alliance: Smarca5tm1Ais page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86695
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment encompassing exons 5 through 9a was replaced with a floxed neo cassette inserted by homologous recombination. The deleted region encoded the catalytic ATPase domain (DEXDc). Protien was undetected in homozygous mutant ES cells by Western blot analysis of nuclear and cytoplasmic extracts. RT-PCR analysis of mutant ES cells corraborated these findings at the RNA level. (J:86695)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smarca5 Mutation:  51 strains or lines available
References
Original:  J:86695 Stopka T, et al., The ISWI ATPase Snf2h is required for early mouse development. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14097-102
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory