Mapk1^tm1Melo
Targeted Allele Detail

Summary

• Symbol: Mapk1^tm1Melo
• Name: mitogen-activated protein kinase 1; targeted mutation 1, Sylvain Meloche
• MGI ID: MGI:2683190
• Synonyms: Erk2^-
• Gene: Mapk1 Location: Chr16:16801246-16865317 bp, + strand Genetic Position: Chr16, 10.53 cM
• Alliance: Mapk1^tm1Melo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85868
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3, which encodes subdomains V and VI, was disrupted by the insertion of a neomycin selection cassette. Protein was undetected in homozygous mutant embyros by Western blot analysis. (J:85868)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk1 Mutation: 43 strains or lines available

References

• Original: J:85868 Saba-El-Leil MK, et al., An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 2003 Oct;4(10):964-8
• All: 8 reference(s)