Lepr^db-5J
Spontaneous Allele Detail

Summary

• Symbol: Lepr^db-5J
• Name: leptin receptor; diabetes 5 Jackson
• MGI ID: MGI:2683234
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^db-5J page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A G-to-T mutation was found in exon 13 effecting a glycine 640 to valine (p.G640V) change in the receptor. (J:87061)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:87061 Leiter EH, et al., Leptin receptor deficiency in NOD/LtJ mice produces a type 2 diadetes syndrome with suppressed autoimmunity. MGI Direct Data Submission. 2004
• All: 3 reference(s)