Tg(PTH-cre)4167Slib
Transgene Detail

Summary

• Symbol: Tg(PTH-cre)4167Slib
• Name: transgene insertion 4167, Steven K Libutti
• MGI ID: MGI:2683304
• Synonyms: PTH-cre, Tg(PTH-cre)1Slib
• Transgene: Tg(PTH-cre)4167Slib Location: unknown
• Alliance: Tg(PTH-cre)4167Slib page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(PTH-cre)4167Slib expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  PTH (5741)

  Pth	(MGI:97799)

• Mutation details: A 5' upstream regulatory region of the human PTH gene was adjoined to sequence encoding cre recombinase followed by a metallothionein 1 polyadenylation signal. The expression of cre recombinase is parathyroid cell specific. (J:86642)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	PTH (human) Summary of all recombinase alleles driven by PTH. Comparative matrix view of recombinase activities Alliance human PTH gene page

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(PTH-cre)4167Slib

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:86642 Libutti SK, et al., Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Cancer Res. 2003 Nov 15;63(22):8022-8
• All: 14 reference(s)