Zap70^m1Saka
Spontaneous Allele Detail

Summary

• Symbol: Zap70^m1Saka
• Name: zeta-chain (TCR) associated protein kinase; mutation 1, Shimon Sakaguchi
• MGI ID: MGI:2683318
• Synonyms: SKG, ZAP-70^skg, ZAP-70^W163C
• Gene: Zap70 Location: Chr1:36800912-36821899 bp, + strand Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
• Alliance: Zap70^m1Saka page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A G-to-T transversion at coding nucleotide 489 (c.489G>T), resulting in a tryptophan to cysteine substitution at codon 163 (p.W163C), was identified on a BALB/c genetic background. (J:86607)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zap70 Mutation: 55 strains or lines available

References

• Original: J:86607 Sakaguchi N, et al., Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature. 2003 Nov 27;426(6965):454-60
• All: 21 reference(s)