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Ppargtm1Auw
Targeted Allele Detail
Summary
Symbol: Ppargtm1Auw
Name: peroxisome proliferator activated receptor gamma; targeted mutation 1, Johan Auwerx
MGI ID: MGI:2683406
Synonyms: PPARgammahyp
Gene: Pparg  Location: Chr6:115337912-115467360 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Alliance: Ppargtm1Auw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86705
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Nucleotide substitutions
 
Mutation detailsA hypomorphic allele was generated by inserting an frt flanked neomycin selection cassette in the intron following exon B. The targeting vector also included a proline to alaline missense mutation at codon 12 (P12A) and loxP sites flanking exon B and the neo cassette. mRNA corresponding to both alternatively spliced transcripts 1 and 2 were significantly reduced in homozygous mutant white adipose tissue. While variant 2 transcript was nearly undetected in homozygous mutant brown adipose tissue, Variant 1 was significantly increased relative to wild-type. (J:86705)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  41 strains or lines available
References
Original:  J:86705 Koutnikova H, et al., Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14457-62
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory