Ppargtm1Auw
Targeted Allele Detail
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Symbol: |
Ppargtm1Auw |
Name: |
peroxisome proliferator activated receptor gamma; targeted mutation 1, Johan Auwerx |
MGI ID: |
MGI:2683406 |
Synonyms: |
PPARgammahyp |
Gene: |
Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
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Alliance: |
Ppargtm1Auw page
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Germline Transmission: |
Earliest citation of germline transmission:
J:86705
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Hypomorph) |
Mutation: |
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Nucleotide substitutions
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Mutation details: A hypomorphic allele was generated by inserting an frt flanked neomycin selection cassette in the intron following exon B. The targeting vector also included a proline to alaline missense mutation at codon 12 (P12A) and loxP sites flanking exon B and the neo cassette. mRNA corresponding to both alternatively spliced transcripts 1 and 2 were significantly reduced in homozygous mutant white adipose tissue. While variant 2 transcript was nearly undetected in homozygous mutant brown adipose tissue, Variant 1 was significantly increased relative to wild-type.
(J:86705)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pparg Mutation: |
41 strains or lines available
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Original: |
J:86705 Koutnikova H, et al., Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14457-62 |
All: |
3 reference(s) |
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