Pparg^tm1.1Auw
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1.1Auw
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Johan Auwerx
• MGI ID: MGI:2683413
• Synonyms: PPARgamma^Pro12Ala
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1.1Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86705
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: The frt flanked neomycin selection cassette was excised from Pparg^tm1Auw via FLP mediated recombination. The proline to alanine missense mutation at codon 12 (exon B) was left intact. The levels of both Pparg1 and Pparg2 transcript in homozygous mutant mice did not significantly differ from those of wild-type. (J:86705)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 41 strains or lines available

References

• Original: J:86705 Koutnikova H, et al., Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14457-62
• All: 3 reference(s)