Gabrr1^tm1Llu
Targeted Allele Detail

Summary

• Symbol: Gabrr1^tm1Llu
• Name: gamma-aminobutyric acid type A receptor subunit rho 1; targeted mutation 1, Luo Lu
• MGI ID: MGI:2683490
• Synonyms: rho1^-
• Gene: Gabrr1 Location: Chr4:33132556-33163606 bp, + strand Genetic Position: Chr4, 14.68 cM
• Alliance: Gabrr1^tm1Llu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86721
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.5 kb genomic fragment encompassing a portion of the promoter region and exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of RNA from spinal cord lumbar segments and retinal tissue. (J:86721)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gabrr1 Mutation: 34 strains or lines available

References

• Original: J:86721 Zheng W, et al., Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord. J Biol Chem. 2003 Nov 28;278(48):48321-9
• All: 6 reference(s)