Hba^tm1Ney
Targeted Allele Detail

Summary

• Symbol: Hba^tm1Ney
• Name: hemoglobin alpha chain complex; targeted mutation 1, Paul A Ney
• MGI ID: MGI:2683492
• Synonyms: Mare^tm1Ney
• Gene: Hba Location: unknown Genetic Position: Chr11, cytoband A

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86682
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 40 bp fragment containing the AP1/NFE2 binding sites of the regulatory element (HS -26) lying within an intron of the Mare gene containing transcription factor binding elements for the mouse alpha-globin genes was replaced with a floxed PGK-neo cassette via homologous recombination. (J:86682)

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hba Mutation: 10 strains or lines available

Notes

ES cell line = E14 (129P2/OlaHsd) or RW-4 (129X1/SvJ).

References

• Original: J:86682 Loyd MR, et al., Role of AP1/NFE2 binding sites in endogenous alpha-globin gene transcription. Blood. 2003 Dec 1;102(12):4223-8
• All: 1 reference(s)