Icosl^tm1Cdon
Targeted Allele Detail

Summary

• Symbol: Icosl^tm1Cdon
• Name: icos ligand; targeted mutation 1, Chen Dong
• MGI ID: MGI:2683493
• Synonyms: B7h^-
• Gene: Icosl Location: Chr10:77904921-77915359 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Icosl^tm1Cdon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86697
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Two loxP sites were inserted so as to flank the two exons encoding the extracellular Ig-like domains as well as an FRT enclosed neomycin resistance gene (Icosl^tm2Cdon. These two exons and the neomycin gene were subsequently removed by crossing F1 mice with a cytomegalovirus-cre transgenic mouse. Absence of protein product was confirmed immunologically. (J:86697)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icosl Mutation: 28 strains or lines available

References

• Original: J:86697 Nurieva RI, et al., B7h is required for T cell activation, differentiation, and effector function. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14163-8
• All: 6 reference(s)