Hba^tm1.1Ney
Targeted Allele Detail

Summary

• Symbol: Hba^tm1.1Ney
• Name: hemoglobin alpha chain complex; targeted mutation 1.1, Paul A Ney
• MGI ID: MGI:2683568
• Synonyms: DeltaNFE2, Mare^tm1.1Ney
• Gene: Hba Location: unknown Genetic Position: Chr11, cytoband A

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86682
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed neo cassette that had replaced the AP1/NFE2 binding sites of Hba regulatory element was excised from Hba^tm1Ney via cre-mediated recombination, leaving a single loxP site in its place. (J:86682)

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hba Mutation: 10 strains or lines available

Notes

ES cell line = E14 (129P2/OlaHsd) or RW-4 (129X1/SvJ).

References

• Original: J:86682 Loyd MR, et al., Role of AP1/NFE2 binding sites in endogenous alpha-globin gene transcription. Blood. 2003 Dec 1;102(12):4223-8
• All: 1 reference(s)