Vav3^tm1Swat
Targeted Allele Detail

Summary

• Symbol: Vav3^tm1Swat
• Name: vav 3 oncogene; targeted mutation 1, Wojciech Swat
• MGI ID: MGI:2683642
• Gene: Vav3 Location: Chr3:109247969-109593014 bp, + strand Genetic Position: Chr3, 48.13 cM, cytoband G1
• Alliance: Vav3^tm1Swat page

Vav2^tm1Kdf/Vav2^tm1Kdf Vav3^tm1Swat/Vav3^tm1Swat mice develop buphthalmos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86654
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 10 was replaced with a floxed neomycin selection cassette inserted by homologous recombination. The deleted region encoded a portion of the Dbl homology domain. Neither full length nor truncated protein was detected by Western blot analysis of splenocytes obtained from homozygous mutant mice. (J:86654, J:97055)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vav3 Mutation: 56 strains or lines available

References

• Original: J:86654 Fujikawa K, et al., Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med. 2003 Nov 17;198(10):1595-608
• All: 41 reference(s)