Mog^tm1Reid
Targeted Allele Detail

Summary

• Symbol: Mog^tm1Reid
• Name: myelin oligodendrocyte glycoprotein; targeted mutation 1, Hugh H Reid
• MGI ID: MGI:2683672
• Synonyms: MOG^-
• Gene: Mog Location: Chr17:37321635-37334290 bp, - strand Genetic Position: Chr17, 19.16 cM, cytoband C
• Alliance: Mog^tm1Reid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86663
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.4 kb genomic fragment, containing the proximal promoter and exon 1, was replaced with a neomycin selection cassette. Protein was undetected by Western blot analysis of homozygous mutant CNS tissue. (J:86663)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mog Mutation: 58 strains or lines available

References

• Original: J:86663 Linares D, et al., The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice. J Autoimmun. 2003 Dec;21(4):339-51
• All: 4 reference(s)