Becn1^tm1Blev
Targeted Allele Detail

Summary

• Symbol: Becn1^tm1Blev
• Name: beclin 1, autophagy related; targeted mutation 1, Beth Levine
• MGI ID: MGI:2683696
• Synonyms: Atg6^-, beclin 1^-
• Gene: Becn1 Location: Chr11:101179084-101193112 bp, - strand Genetic Position: Chr11, 64.58 cM, cytoband D
• Alliance: Becn1^tm1Blev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86953
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 1 and 2 were replace with a neomycin selection cassette inserted by homologous recombination. (J:86953)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Becn1^tm1Blev

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Becn1 Mutation: 36 strains or lines available

References

• Original: J:86953 Qu X, et al., Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003 Dec;112(12):1809-20
• All: 58 reference(s)