Susp^ALS/Lt
QTL Variant Detail

Summary

• QTL variant: Susp^ALS/Lt
• Name: suppressor of superoxide production; ALS/Lt
• MGI ID: MGI:2683702
• QTL: Susp Location: Chr3:66495005-66495118 bp Genetic Position: Chr3, cM position of peak correlated region/allele: 30.51 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: ALR/Lt

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased superoxide production compared to ALR/Lt.
• Inheritance: Codominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:76108

44 animals from an (ALS/Lt x ALR/Lt)F1 x ALS/Lt backcross were genotyped at 68 polymorphic loci to identify QTLs associated with resistance to oxidative stress. Parental strain ALS/Lt is susceptible to oxidative stress where as parental strain ALR/Lt is resistant to oxidative stress and exhibits a suppressed neutrophil superoxide burst.

A locus named Susp (suppressor of superoxide production) mapped to approximately 33 cM on mouse Chromosome 3 with P < 0.0001 at D3Mit241. The QTL interval of Susp spans25 cM - 45 cM. ALR/Lt-derived alleles confer reduced superoxide production at Susp in a codominant manner. Possible candidate genes mapping to the Susp interval are Etfdh, Rap1a, Il12a, Il6ra, and Arnt.

References

• Original: J:76108 Mathews CE, et al., Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice. Free Radic Biol Med. 2002 Apr 15;32(8):744-51
• All: 1 reference(s)