St14^tm2Bug
Targeted Allele Detail

Summary

• Symbol: St14^tm2Bug
• Name: suppression of tumorigenicity 14 (colon carcinoma); targeted mutation 2, Thomas H Bugge
• MGI ID: MGI:2683723
• Gene: St14 Location: Chr9:31000698-31043149 bp, - strand Genetic Position: Chr9, 16.61 cM
• Alliance: St14^tm2Bug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86715
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was replaced with a neomycin selection cassette. (J:86715)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any St14 Mutation: 45 strains or lines available

References

• Original: J:86715 List K, et al., Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1. J Cell Biol. 2003 Nov 24;163(4):901-10
• All: 4 reference(s)