Tnfsf4^tm1Shr
Targeted Allele Detail

Summary

• Symbol: Tnfsf4^tm1Shr
• Name: tumor necrosis factor (ligand) superfamily, member 4; targeted mutation 1, Arlene H Sharpe
• MGI ID: MGI:2683777
• Synonyms: Ox40L^-/-, OX40L^o
• Gene: Tnfsf4 Location: Chr1:161223009-161245777 bp, + strand Genetic Position: Chr1, 69.75 cM
• Alliance: Tnfsf4^tm1Shr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59203
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette inserted by homologous recombination replaced the exon encoding the entire extracellular domain and a portion of the 3' untranslated region. Protein was undetected by flow cytometric analysis of activated homozygous mutant dendritic cells. (J:59203)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf4 Mutation: 33 strains or lines available

References

• Original: J:59203 Chen AI, et al., Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity. 1999 Dec;11(6):689-98
• All: 7 reference(s)