Becn1^tm1Htz
Targeted Allele Detail

Summary

• Symbol: Becn1^tm1Htz
• Name: beclin 1, autophagy related; targeted mutation 1, Nathaniel Heintz
• MGI ID: MGI:2683833
• Synonyms: Beclin^-
• Gene: Becn1 Location: Chr11:101179084-101193112 bp, - strand Genetic Position: Chr11, 64.58 cM, cytoband D
• Alliance: Becn1^tm1Htz page

Increased cancer rate in Becn1^tm1Htz/Becn1⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86982
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 and 1.6 kb of upstream sequence were replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of homozygous mutant ES cells. (J:86982)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Becn1^tm1Htz

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Becn1 Mutation: 36 strains or lines available

References

• Original: J:86982 Yue Z, et al., Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15077-82
• All: 26 reference(s)